The story is told entirely through documents: journals, letters, telegrams, newspaper cuttings, and phonograph recordings, gathered afterward so that an almost unbelievable history can stand forth as plain fact. It opens with the journal of Jonathan Harker, a young English solicitor who travels into the Carpathians to finalize a London property purchase for a mysterious client, Count Dracula. The local people cross themselves and press charms on him as he goes.
At the castle Harker slowly realizes he is a prisoner. His host keeps no servants, casts no reflection, and crawls face-down along the outer walls like a lizard. Studying the Count's books and letters, Harker grasps the plan: Dracula has taught himself England from atlases and directories and means to move there to walk among the living. Harker is left behind, trapped, as the Count departs for the coast with boxes of his native earth.
In England the narrative widens to Mina Murray, Harker's fiancee, and her friend Lucy Westenra, who sickens after the Count's ship runs aground at Whitby. Lucy wastes away despite repeated blood transfusions, and her doctor, Seward, calls in his old teacher, Professor Van Helsing, who alone recognizes the cause. Lucy dies, returns as a predatory creature, and must be released from undeath by her own grieving friends.
The survivors form a band: Harker and Mina, Seward, Lord Godalming, the American Quincey Morris, and Van Helsing. They hunt the Count's hidden boxes of earth across London, but he strikes back by feeding on Mina and forcing his own blood on her, marking her as half his and tainting her with his thoughts. Branded unclean, she becomes both a victim and, through her link to him, a means of tracking his flight.
Driven from England, the Count flees by sea back toward Transylvania in a last box of earth. The band pursues him overland, racing his gypsy escort to the castle before sundown. They overtake the cart at dusk; Harker shears through the Count's throat and Morris drives a knife into his heart, and the body crumbles to dust as the curse lifts from Mina's brow. Morris dies of his wound, and a closing note remarks that almost nothing in their record would count as proof.