An unnamed young wife narrates in secret diary fragments. For the summer she and her husband John have taken an isolated colonial mansion, and she has been brought there to recover from what John, a physician of high standing, calls a temporary nervous depression. She suspects there is something queer about the place, and something more the matter with her than he will admit, but as she notes early on, he does not believe she is really sick.
John prescribes a strict regimen of rest, air, tonics, and absolutely no work, least of all the writing she loves; she keeps her journal only in stolen moments, hiding it whenever he or his sister Jennie appears. The couple sleep not in the pretty downstairs room she wanted but in a large former nursery at the top of the house, its windows barred, a heavy bed nailed to the floor, the walls covered in a sprawling, smouldering yellow paper she finds repellant.
With nothing to occupy her, she begins to study that paper by the hour. Its formless sub-pattern resolves, in certain lights, into a figure: a woman stooping and creeping behind the front design, as if behind bars. Each time she tries to tell John she is not improving and begs to leave, he reassures, overrules, or gently scolds her, and she falls silent, growing more secretive, more tired, and quietly afraid of him.
As the weeks pass the wallpaper takes over completely. She smells it through the whole house, traces a long smooch worn round the room, and becomes convinced the woman behind the pattern shakes it and tries to climb through, and that by day she creeps free in the garden and lanes outside. The narrator resolves to free her, telling no one, certain that John and Jennie are secretly after the same discovery and must be kept from it.
On the last day before they are to leave she locks herself in, throws the key down the path, and tears off all the paper she can reach, until she comes to believe she herself is the woman who has at last got out. When John breaks in he finds her creeping along the wall, announcing she has escaped in spite of him and cannot be put back. He faints across her path, and she creeps on over him, the rest cure complete in ruin.